Activision Seeks Closure of Domain

A few years back, someone was alert enough to snag, a domain Activision apparently didn’t see any use for. Now they do, mostly because the site existed as an anti-Call of Duty promo, featuring either parodies of COD, or redirecting people over to the Battlefield 3 website.

EA claims their hands are clean in the mess, although they’re certainly laughing somewhere in a dark corner. Activision claims they have full rights to the domain name, filing a $2,600 dispute with the National Arbitration Forum over the URL. The site was registered over a proxy, so the actual owner is unknown. However, Activision’s reasons for filing the claim are, well, not particularly strong:

“It appears that the Respondent supports the game Battlefield from the game developer Electronic Arts (“EA”).  EA is one of Complainant’s principal competitors in the video game industry, and Battlefield game competes in the marketplace with Complainant’s MODERN WARFARE games and its other military-themed shooter games in the CALL OF DUTY series.”

So, because it’s competition, a fan site, hoax or not, can’t exist? Good luck with that Activision.

Classification of loratadine and possible therapeutic significance reported.

Biotech Week December 29, 2004 2004 DEC 29 – ( & — Scientists from Croatia have reported on the classification of loratadine based on the biopharmaceutics drug classification concept and possible in vitro-in vivo correlation.

“Loratadine was studied both in vitro and in vivo (in healthy humans) to classify it according to the Biopharmaceutics Classification System (BCS) in order to gain more understanding of the reasons for its highly variable nature with respect to plasma time profiles,” wrote M.Z.I. Khan and colleagues, PLIVA Research Institute, “and to determine the most appropriate dissolution test conditions for in vitro assessment of the release profile of the drug from solid dose forms.

“Based on the solubility of loratadine determined under various pH conditions and its permeability through Caco-2 monolayers, loratadine was classified as a Class 11 drug. web site loratadine side effects

“Plasma profiles were predicted by convolution analysis using dissolution profiles obtained under various pH and hydrodynamic conditions as the input function and plasma time data obtained from a syrup formulation as the weighting function,” continued the researchers.

“The predicted profiles based on dissolution studies done at gastric pH values were in reasonable agreement with the mean bio-data suggesting dissolution testing should be done at gastric pH values.” “However,” the researchers concluded, “the bio-data were highly variable and it is suggested this may be due, at least in part, to high individual gastric pH variability and dissolution occurring in the intestine on some occasions, and therefore, dissolution testing should also be done in simulated intestinal fluid.” Khan and colleagues published their study in Biological & Pharmaceutical Bulletin (Classification of loratadine based on the biopharmaceutics drug classification concept and possible in vitro-in vivo correlation. Biol Pharm Bull, 2004;27(10):1630-1635). website loratadine side effects

Additional information can be obtained by contacting M.Z.I. Khan, PLIVA Research Institute Ltd, Prilaz Baruna Filipovica 29, Zagreb 10000, Croatia.

The publisher of the journal Biological & Pharmaceutical Bulletin can be contacted at: Pharmaceutical Society Japan, 2-12-15-201 Shibuya, Shibuya-Ku, Tokyo, 150, Japan.

The information in this article comes under the major subject areas of Biopharmaceutics, Lortadine, Permeability Testing and Therapy.